Patients who are on warfarin need to be aware of the effects of warfarin .
Patients undergoing valve replacement with a mechanical valve will need tobe put on warfarin lifelong .
Foods containing vitamin k can affect how warfarin works .
They include green leafy vegetables
Brocoli spinach and lettuce
Chickpeas
Liver
Egg yolks
Mature cheese
Avocado
Olive oil
Eating in moderation is recommended .
Cranberry and grapefruit avoided .
Dosage .depends on body weight to be taken in evening . Start with 10 mg and then reduce gradually . Daily inr is a must . Different indication have varied dosage .
Effect of warfarin to manifest takes 48 hours . So patients are put on heparin to bridge the gap .
Regular blood test of inr is needed to titrate dosage of warfarin . High inr suggests the time taken to clot as compared to normal.
Every day inr level is required till the target is reached . Then inr will be needed every 12 weekly .
Warfarin interacts with other medications too .
Medicines such as amiodarone and quinidine for heart .
Non steroidal anti inflammatory like ibuprofen ,aspirin
Cholesterol lowering agents benzafibrate, clofibrate
Antibiotics such as erythromycin , cotrimoxazole , norfloxacin
Miconiazole
It is safe to take paracetamol.
Warfarin is not reccomended during pregnancy . If required then it has to be taken under supervision if doctor says baby is healthy then it is ok to take warfarin . Cause of concern if baby bleeds or bruise easily . Baby is not feeding well then go to doctor .
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